Interactions
Every interaction in our database, with the evidence behind it.
This is general information, not medical advice. Supplements can interact with medicines and health conditions. Always check with your doctor or pharmacist before starting or changing supplements.
- Avoid combining5-Hydroxytryptophan and Selective serotonin reuptake inhibitors (SSRIs)
- Use cautionAshwagandha and Selective serotonin reuptake inhibitors (SSRIs)
- Use cautionAshwagandha and Thyroid hormones
- MonitorBiguanides and Creatine
- Supportive pairingBiguanides and Multi-Strain Probiotic
- Supportive pairingBiguanides and Vitamin B12 (Cobalamin)
- Separate timingBile acid sequestrants and Omega-3 Fatty Acids (EPA/DHA)
- Separate timingBile acid sequestrants and Vitamin D3 (Cholecalciferol)
- Separate timingBile acid sequestrants and Vitamin K2 (Menaquinone)
- Supportive pairingCreatine and Selective serotonin reuptake inhibitors (SSRIs)
- MonitorCreatine and Tenofovir disoproxil / emtricitabine
- MonitorDirect oral anticoagulants (DOACs) and Omega-3 Fatty Acids (EPA/DHA)
- Supportive pairingMagnesium and Proton pump inhibitors (PPIs)
- Separate timingMagnesium and Thyroid hormones
- Supportive pairingMulti-Strain Probiotic and Proton pump inhibitors (PPIs)
- Supportive pairingOmega-3 Fatty Acids (EPA/DHA) and Statins (HMG-CoA reductase inhibitors)
- MonitorOmega-3 Fatty Acids (EPA/DHA) and Vitamin K antagonists
- Supportive pairingProton pump inhibitors (PPIs) and Vitamin B12 (Cobalamin)
- Supportive pairingTenofovir disoproxil / emtricitabine and Vitamin D3 (Cholecalciferol)
- Supportive pairingVitamin B-Complex and Biguanides
- Supportive pairingVitamin B-Complex and Proton pump inhibitors (PPIs)
- Supportive pairingVitamin B12 (Cobalamin) and Folate (Vitamin B9)
- Avoid combiningVitamin K antagonists and Vitamin K2 (Menaquinone)
We check against a limited set of medications. Absence of a warning here is not evidence of safety. Always confirm with your pharmacist.
Medicines we do not check yet
The checker knows nothing about these, so it will not warn you about them. They are listed here precisely so that gap is visible rather than silent. A medicine is only added once its interactions are researched and cited, because a medicine with no interaction data would make the checker answer 'no interactions found' for combinations that genuinely matter.
- Fluoroquinolone antibiotics Ciprofloxacin and its relatives bind to magnesium and other minerals in the gut, which can sharply reduce how much antibiotic is absorbed — a timing interaction that matters for anyone on the supplements this site already covers.
- ACE inhibitors Enalapril, perindopril and their relatives are among the most commonly prescribed blood pressure medicines in South Africa, and they change how the body handles potassium and other electrolytes that supplements can add to.
Not seeing a medicine you take? Ask us to add it. Requests are how we decide what to research next.