Can you take Magnesium with Proton pump inhibitors (PPIs)?
This is general information, not medical advice. Supplements can interact with medicines and health conditions. Always check with your doctor or pharmacist before starting or changing supplements.
What the evidence says
Long-term PPI use can lower the body's magnesium, most likely by reducing how much magnesium the intestine absorbs. A 2019 meta-analysis of 16 observational studies covering more than 131,000 patients found PPI users had significantly higher odds of low blood magnesium (adjusted odds ratio 1.71), with high-dose PPI use roughly doubling the odds compared with low-dose use. The severe end of this is well documented: a published case series — one patient was on omeprazole itself — describes dangerously low magnesium after one to thirteen years of PPI use, together with low calcium, low potassium, and heart rhythm abnormalities. The evidence is observational, so it cannot prove every PPI user loses magnesium, and most users never develop a problem. Taking a magnesium supplement alongside a PPI is a supportive pairing rather than a risk, but do not use it to self-treat symptoms: if you are on a PPI long-term, ask your prescriber to check your magnesium level, and report muscle cramps, tremor, or palpitations promptly, because severe cases usually need the PPI itself reviewed rather than just more magnesium.
Read more
We check against a limited set of medications. Absence of a warning here is not evidence of safety. Always confirm with your pharmacist.